Immunization regimen with e4-deleted adenovirus prime and...

Details Immunization regimen with e4-deleted adenovirus prime and... Immunization regimen with e4-deleted adenovirus prime and...

A - Human Necessities

61

K

A61K 39/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2563500

An immunization regimen is provided which involves priming with an E1, E4- deleted adenovirus and boosting with an E1-deleted adenovirus. The second administered adenovirus has a capsid of a serotype which is not cross-reactive with the previously administered adenovirus. Further, a product containing the adenoviruses necessary to perform the immunization regimen is provided.

L'invention concerne un schéma d'immunisation qui consiste à effectuer une première immunisation avec un adénovirus à E1, E4 supprimé et une immunisation de rappel avec un adénovirus à E1 supprimé. Le deuxième adénovirus administré possède une capside d'un sérotype sans activité croisée avec l'adénovirus déjà administré. En outre, l'invention concerne un produit contenant l'adénovirus nécessaire pour mettre en place le schéma d'immunisation.

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