C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/08 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2574218
Disclosed are novel compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4 and X are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are methods of treating a cognitive or neurodegenerative disease comprising administering to a patient I need of such treatment a combination of at least one compound of formula (I) and at least one compound selected from the group consisting of .beta.-secretase inhibitors other than those of formula (I), HMG-CoA reductase inhibitors, gamma-secretase inhibitors, non-steroidal anti-inflammatory agents, N-methyl-D-aspartate receptor antagonists, cholinesterase inhibitors and anti-amyloid antibodies.
L'invention porte sur de nouveaux composés de la formule (I) ou un sel ou un solvant pharmaceutiquement acceptables de ceux-ci, R1, R2, R3, R4 et X étant tels que définis dans le descriptif. L'invention concerne aussi des compositions pharmaceutiques contenant les composés de la formule (I). Elle se rapporte également à des procédés de traitement de maladies cognitives ou neurodégénérescentes tels que la maladie d'Alzheimer. L'invention concerne aussi des procédés de traitement d'une maladie cognitive ou neurodégénérescente consistant à administrer à un patient ayant besoin de ce traitement une combinaison d'au moins un composé de la formule (I) et au moins un composé choisi dans le groupe des inhibiteurs de ß-secretase autres que ceux de la formule (I), des inhibiteurs de HMG-CoA reductase, des inhibiteurs de gamma-secretase, des agents anti-inflammatoires non stéroïdiques, des antagonistes du récepteur de N-methyl-D-aspartate, des inhibiteurs de cholinesterase et des anticorps anti-amyloïdes.
Huang Ying
Li Guoqing
Stamford Andrew W.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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