C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/55 (2006.01) C07D 221/00 (2006.01) C07D 243/00 (2006.01) C07D 265/00 (2006.01) C07D 279/00 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2360767
The invention is directed to tricyclic benzodiazepines of the formula (I) or (II): useful as vasopressin receptor an-tagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
L'invention concerner des benzodiazépines tricycliques utiles en tant qu'antagonistes du récepteur de la vasopressine, pour le traitement d'états impliquant une résistance vasculaire et une insuffisance cardiaque élevées. Sont également décrits des compositions pharmaceutiques comprenant les benzodiazépines de l'invention et des méthodes de traitement d'états tels que l'hypertension, l'insuffisance cardiaque, l'insuffisance cardiaque globale, le vasospasme coronarien, l'ischémie cardiaque, la cirrhose du foie, le vasospasme rénal, l'oedème et l'ischémie pulmonaires, l'attaque, la thrombose ou la rétention d'eau.
Dyatkin Alexey B.
Hoekstra William J.
Maryanoff Bruce E.
Matthews Jay M.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Mcneil Pharmaceutical Inc.
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