Peptides of il1 beta and tnf alpha and method of treatment...

Details Peptides of il1 beta and tnf alpha and method of treatment... Peptides of il1 beta and tnf alpha and method of treatment...

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2557654

The present invention relates to peptides derived from the proinflammatory cytokines, interleukin-1~, (IL1~) and tumor necrosis factor .alpha., (TNF.alpha.), and their use in human or veterinary therapy, such as to generally treat diseases linked to the overproduction of IL1~ or TNF.alpha. as well as acute or chronic inflammatory diseases, rheumatoid arthritis, septic shock, autoimmune diabetes, graft rejection in the host, etc.

L'invention concerne des peptides dérivés des cytokines proinflammatoires, de l'interleukine-1ß, (IL1ß), et du facteur de nécrose des tumeurs .alpha., (TNF.alpha.), et l'utilisation de ces peptides pour les traitements thérapeutiques de patients humains et animaux, notamment le traitement de maladies associées à un surproduction d'IL1ß ou de TNF.alpha., ainsi que des maladies inflammatoires aiguës ou chroniques, de la polyarthrite rhumatoïde, des chocs septiques, du diabète autoimmun, des rejets de greffes par l'hôte etc.

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