A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2603896
RNAIII-inhibiting peptide (RIP) advantageously treats or reduces the risk of biofilm formation on implanted bone cement, thus reducing the possibility of sustained chemotherapy, hospitalization, or surgical removal of the bone cement. Unlike antibiotics, RIP eradicates biofilms without inducing resistant bacterial strains, making RIP particularly advantageous in this application. Biodegradable compositions comprising RIP also are provided.
Selon cette invention, un peptide inhibiteur de l'ARNIII (RIP) présente l'avantage de traiter ou de réduire le risque de formation de film biologique sur un ciment osseux implanté, ce qui réduit le risque de chimiothérapie prolongée, d'hospitalisation, ou d'ablation par chirurgie du ciment osseux. Contrairement aux antibiotiques, le peptide (RIP) élimine les films biologiques sans induire de souches bactériennes résistantes, ce qui rend le peptide RIP particulièrement bénéfique dans cette application. Cette invention concerne également des compositions biodégradables comprenant le peptide.
Balaban Naomi
Blake Cassels & Graydon Llp
LandOfFree
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