Chelated 8-hydroxyquinoline for the treatment of epithelial...

Details Chelated 8-hydroxyquinoline for the treatment of epithelial... Chelated 8-hydroxyquinoline for the treatment of epithelial...

A - Human Necessities

61

K

A61K 33/30 (2006.01) A61K 31/47 (2006.01) A61K 33/24 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2320628

Oxinates including 8-hydroxyquinoline and a heavy metal are topically applied to epidermal lesions for therapeutic effect. The therapeutic composition demonstrates selective toxicity with a therapeutic index of one-hundred percent on human lung cancer, breat cancer, melanoma, venereal warts, male veruoca warts, lesions produced by human papilloma virus, basal cell carcinoma, solarkeratosis, and Kaposi's sarcoma. In veterinary applications where dogs, cats, and horses are the patients, the composition shows a one-hundred percent therapeutic index with selective toxicity against eye cancer, sarcoids, sarcoma, malignant melanoma, rectal adenoma, histiocytoma, and sebaceous adenoma.

La présente invention concerne des oxinates comprenant de la 8-hydroxyquinoléine et un métal lourd que l'on applique localement sur des lésions de l'épiderme afin d'obtenir un effet thérapeutique. La composition thérapeutique de la présente invention présente une toxicité sélective et un index thérapeutique de cent pour cent sur le cancer du poumon, le cancer du sein, le mélanome, les condylomes acuminés, les verrues vénériennes masculines, les lésions produites par le papillomavirus humain, le carcinome basocellulaire, la kératose solaire et le sarcome de Kaposi. Dans des applications vétérinaires où les patients sont des chiens, des chats et des chevaux, la composition présente un index thérapeutique de cent pour cent et une toxicité sélective contre le cancer de l'oeil, les sarcoïdes, le sarcome, le mélanome malin, l'adénome rectal, l'histiocytome et l'adénome sébacé.

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