Prion protein binding materials and methods of use

Details Prion protein binding materials and methods of use Prion protein binding materials and methods of use

G - Physics

01

N

G01N 33/543 (2006.01) A23L 1/015 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) C02F 1/28 (2006.01) C07K 1/22 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2582462

Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.

L'invention porte sur des liants des protéines prions, et des procédés d'utilisation de ces liants pour la détection ou l'extraction d'une protéine prion présente dans un échantillon, tel qu'un fluide biologique ou un échantillon de milieu. Les liants décrits peuvent se lier avec une ou de plusieurs formes de prions, notamment la protéine prion cellulaire (PrPc), la protéine prion infectieuse (PrPsc), la protéine prion recombinée (PrPr), et la protéine prion résistante à la protéinase (PrPres). Les prions de diverses espèces, notamment de l'humain, et du hamster sont fixés par les liants décrits.

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