Piperidyl-propane-thiol ccr3 modulators

Details Piperidyl-propane-thiol ccr3 modulators Piperidyl-propane-thiol ccr3 modulators

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2667547

One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.

L'invention concerne des nouveaux pipéridyl-propane-thiols substitués de formule (1), dans laquelle R1, R2, R3 et R4 ont la signification indiquée dans la description. L'invention propose également des agonistes ou des antagonistes de CCR-3, ou des sels acceptables sur le plan pharmaceutique de ceux-ci, plus particulièrement des compositions pharmaceutiques qui comprennent un excipient acceptable sur le plan pharmaceutique et une dose efficace sur le plan thérapeutique d'au moins un des composés de la présente invention ou d'un sel acceptable sur le plan pharmaceutique de ceux-ci.

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