Methods and compositions for treating hyperproliferative...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61K 31/497 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2476000

The present invention relates to a combination which comprises (a) an inhibitor of a tissue non-specific growth factor receptor and (b) an inhibitor of a tissue specific growth factor receptor for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of phyperproliferative conditions, such as in particular cancer, in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating hyperproliferative conditions, such as especially cancer, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.

L'invention concerne une combinaison comprenant : (a) un inhibiteur de r~cepteur de facteur de croissance non sp~cifique tissulaire et (b) un inhibiteur de r~cepteur de facteur de croissance non sp~cifique tissulaire pour une utilisation simultan~e, concurrente, s~par~e ou s~quentielle, plus particuli­rement pour une utilisation dans le traitement d'~tats hyperprolif~ratifs, tels que notamment le cancer, chez des mammif­res et particulier, chez l'homme. L'invention concerne en outre des compositions pharmaceutiques comprenant ladite combinaison et une m~thode de traitement d'~tats hyperprolif~ratifs, tels que notamment le cancer, ~ l'aide d'une telle combinaison. Ladite invention concerne en outre un emballage commercial ou un produit commercial comprenant une telle combinaison.

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