A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 9/70 (2006.01) A61K 31/417 (2006.01) A61K 31/66 (2006.01)
Patent
CA 2336004
Use of a histamine H2 mimicking substance for the manufacture of a medicament for the treatment of multiple sclerosis. The histamine H2 mimicking agent is present in an amount which is effective to stimulate production of a cyclic AMP in the body. A phosphodiesterase inhibitor is used in conjunction with the histamine H2 mimicking agent to conserve the cyclic AMP which is thus produced. It is believed that the increased cyclic AMP levels serve to maintain the patient's myeline against self degeneration. The histamine H2 mimicking agent may be histamine phosphate and the phosphodiesterase inhibitor may be caffeine. The histamine H2 mimicking agent and the phosphodiesterase inhibitor may be mixed in a gel and administered using a transdermal patch.
L'invention se rapporte à l'utilisation d'une substance imitant l'histamine H2 pour la fabrication d'un médicament destiné au traitement de la sclérose en plaques. Ledit agent imitant l'histamine H2 est présent en quantité suffisante pour stimuler la production par le corps d'AMP cyclique. On utilise un inhibiteur de phosphodiestérase en association avec l'agent imitant l'histamine H2 afin de conserver l'AMP cyclique ainsi produite. On pense que l'accroissement des taux d'AMP cyclique permet d'éviter l'auto-dégénérescence de la myéline du patient. Ledit agent imitant l'histamine H2 peut être du phosphate d'histamine et l'inhibiteur de phosphodiestérase peut être de la caféine. On peut mélanger l'agent imitant l'histamine H2 et l'inhibiteur de phosphodiestérase de façon à obtenir un gel que l'on administre au moyen d'un timbre transdermique.
Borden Ladner Gervais Llp
Delack Elaine A.
LandOfFree
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