C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/435 (2006.01)
Patent
CA 2557256
The invention relates to polymorphous forms of (+)-(S)-clopidogrel hydrogen bromide, described as polymorphous "form A", polymorphous "form B", polymorphous "form C", polymorphous "form D", polymorphous "form E", and polymorphous "form F", in addition to polymorphous forms of (+)-(S)- clopidogrel napsylate, that are described as polymorphous "form A" and polymorphous "form B" and differ in the X-ray powder diffraction diagrams (XRPD) thereof. The invention also relates to the salts clopidogrel besylate, clopidogrel tosylate and clopidogrel oxalate, and to methods for the production thereof.
La présente invention concerne des formes polymorphes de bromure d'hydrogène de (+)-(S)-clopidogrel, qui sont mentionnées en tant que "forme A" polymorphe, "forme B" polymorphe, "forme C" polymorphe, "forme D" polymorphe, "forme E" polymorphe et "forme F" polymorphe, ainsi que des formes polymorphes de napsylate de (+)-(S)-clopidogrel, qui sont mentionnées en tant que "forme A" polymorphe et "forme B" polymorphe et qui se différencient entre elles par leurs diagrammes de diffraction des rayons X sur poudre (XRPD), ainsi que les sels bésylate de clopidogrel, tosylate de clopidogrel et oxalate de clopidogrel et des procédés pour les préparer.
Levis Michael Karl
Ly Hon Quang
Weber Beat T.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Siegfried Generics International Ag
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