A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) C12N 7/04 (2006.01) C12N 7/06 (2006.01) C12N 15/37 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2384844
Human papillomavirus virus-like particles (VLPs) are subjected to various maturation conditions, including incubation at higher temperatures, exposure to soluble metals or thios-oxidation. The resultant matured VLPs are of various sizes (see the figure), are more stable, and can be used to make a vaccine formulation with increased shelf life and higher potency.
L'invention revient à soumettre à des conditions de maturation des particules présentant l'aspect viral du papillomavirus humain. Ces conditions impliquent notamment l'incubation à des températures supérieures, une exposition à des métaux solubles ou une oxydation par les thios. Ces particules d'aspect viral résultant de la maturation sont plus stables et conviennent à la réalisation d'une formulation vaccinale puis puissante et de durée de conservation plus longue.
Gadam Shishir
Manger Walter
Wu Shilu
Zhao Qinjian
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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