Novel orthosomycins from micromonospora carbonacea

Details Novel orthosomycins from micromonospora carbonacea Novel orthosomycins from micromonospora carbonacea

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) C07H 17/04 (2006.01) C07H 19/01 (2006.01)

Patent

CA 2234164

Compounds of the formulae (see formula I) R1 R2 R3,R3' R4 R5 R6 evernino micrin H OH OH,H OMe Cl Me Compd A CI OH OH,H OMe Cl Me Compd B H OH =O OMe Cl Me Compd D H OMe OH,H OMe Cl Me Compd E H OH OH,H OH H Me Compd F H OH OH,H OMe H Me Compd G H OH OH,H OMe Cl H; or Image wherein R7=CH3; R8=CH3; (Compound C) or R7=C(O)H; R8 =H (Compound H), or Image and pharmaceutically acceptable salts thereof, or orthosomycins which have been isolated from the fermentation broth of the microorganism Micromonospora Carbonacea var Africano designated SCC 2146, these compounds are antibacterial agents useful in treating bacterial infections.

Des orthosomycines ont été isolées du bouillon de fermentation du microorganisme Micromonospora Carbonacea var Africana, désigné par SCC 2146. Ces composés sont des agents antibactériens. La présente invention concerne aussi des compositions et des procédés de traitement d'infections bactériennes.

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