C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/02 (2006.01) A61K 31/4184 (2006.01) A61K 31/4192 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61P 35/00 (2006.01) C07D 249/16 (2006.01) C07D 271/12 (2006.01) C07D 285/14 (2006.01)
Patent
CA 2411924
Compunds of the formula I or II wherein X is CY or N, and W is O or S, modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
L'invention concerne des composés de la formule (I) ou de la formule (II) dans laquelle X est CY ou N, et W est O ou S, lesdits composés modulant et/ou inhibant l'activité des certaines protéines kinases. Les composés de l'invention et les compositions pharmaceutiques qui les contiennent peuvent induire une transduction de signal de la tyrosine kinase afin de moduler et/ou d'inhiber une prolifération cellulaire indésirée. L'invention concerne également l'utilisation thérapeutique ou prophylactique de compositions pharmaceutiques contenant ces composés, et des méthodes de traitement du cancer ainsi que d'autres états pathologiques associés à une angiogenèse non désirée et/ou une prolifération cellulaire, telle que la rétinopathie diabétique, le glaucome, la polyarthrite rhumatoïde, et le psoriasis, par administration de quantités effectives de tels composés.
Chong Wesley Kwan Mung
Duvadie Rohit Kumar
Agouron Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
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