Benzothiepine ileal bile acid transport inhibitors

Details Benzothiepine ileal bile acid transport inhibitors Benzothiepine ileal bile acid transport inhibitors

C - Chemistry, Metallurgy

07

D

C07D 337/08 (2006.01) A61K 31/38 (2006.01) A61P 3/06 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2459445

The present invention relates to compounds of formula (I) wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

La présente invention concerne des composés de la formule (I) dans laquelle des groupes variables sont tels que définis dans le mémorandum descriptif. Elle concerne des sels pharmaceutiquement acceptables, des solvates, des solvates de ces sels et des promédicaments desdits composés, et leur utilisation comme inhibiteurs de transport des acides biliaires présents dans l'iléon (IBAT) destinés au traitement de l'hyperlipidémie. L'invention concerne en outre leur fabrication et des compositions pharmaceutiques qui les contiennent.

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