6-substituted sulfonyl azabicyclo[3.2.1]octanes useful to...

Details 6-substituted sulfonyl azabicyclo[3.2.1]octanes useful to... 6-substituted sulfonyl azabicyclo[3.2.1]octanes useful to...

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/33 (2006.01) A61P 5/00 (2006.01)

Patent

CA 2696288

In its many embodiments, the present invention relates to a novel class of 6-substituted sulfonyl-1,3,3-trialkyl-6-az-abicyclo[3.2.1]octane compounds useful to inhibit 11.beta.-hydroxysteroid dehydrogenase type-I, pharmaceutical compositions contain-ing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11.beta.-hydroxysteroid dehydrogenase type-I using such compounds or pharmaceutical compositions.

L'invention concerne, dans ses nombreux modes de réalisation, une nouvelle classe de composés de sulfonyl-1,3,3-trialkyl-6-azabicyclo[3.2.1]octane substitués en position 6 utiles pour inhiber la 11b-hydroxystéroïde déshydrogénase de type I, des compositions pharmaceutiques contenant les composés, et des procédés de traitement, de prévention, d'inhibition, ou d'amélioration d'un ou de plusieurs affections associées à l'expression de la 11b-hydroxystéroïde déshydrogénase de type I en utilisant de tels composés ou compositions pharmaceutiques.

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