A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 35/42 (2006.01) A61K 47/24 (2006.01)
Patent
CA 2244767
The invention concerns a process for the production of a powdered pulmonary surfactant preparation containing a hydrophobic protein serving as a pulmonary surfactant characterized by the fact that an organic solution or suspension containing a hydrophobic protein serving as a pulmonary surfactant and possibly other components is subject to spray drying. Powder preparations are obtained that exhibit very good stability under storage, are easy to reconstitute and which are also suitable for administration by inhalation.
L'invention concerne un procédé permettant de fabriquer une préparation de surfactant pulmonaire en poudre qui contient une protéine hydrophobe faisant fonction de surfactant pulmonaire, caractérisé par le fait que l'on soumet à une déshydratation par pulvérisation une solution ou une suspension organique contenant une protéine surfactant pulmonaire et éventuellement d'autres composants. On obtient ainsi des préparations en poudre qui présentent une très bonne stabilité au stockage, qui sont faciles à reconstituer et qui peuvent également être administrées par inhalation.
Byk Gulden Lomberg Chemische Fabrik Gmbh
Gowling Lafleur Henderson Llp
Nycomed Gmbh
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