C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/16 (2006.01) A61K 38/46 (2006.01) A61P 3/10 (2006.01) A61P 37/06 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/46 (2006.01) C07K 14/62 (2006.01) C12N 9/88 (2006.01) C40B 30/04 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2370763
The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includes peptides derived from the IA-2 polypeptide by such a method, altered peptide ligands, and methods of therapy involving the use of altered peptide ligands.
La présente invention concerne des procédés d'identification des épitopes peptidiques activant les lymphocytes T auxiliaires impliqués dans la pathogénie des infections, par exemple des maladies auto-immunes, la sensibilité pour lesquelles est déterminée par l'expression d'un des gènes spécifiques de CMH de classe II. L'invention concerne également des peptides dérivés du polypeptide IA-2 par un tel procédé, des ligands peptidiques modifiés, et des méthodes thérapeutiques comportant l'utilisation des ligands peptidiques modifiés.
Chicz Roman M.
Peakman Mark
Eisai Inc.
King's College London
Smart & Biggar
Zycos Inc.
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