Diazepan and piperazine derivatives modulators of chemokine...

Details Diazepan and piperazine derivatives modulators of chemokine... Diazepan and piperazine derivatives modulators of chemokine...

C - Chemistry, Metallurgy

07

D

C07D 241/08 (2006.01) A61K 31/4965 (2006.01) A61K 31/551 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) C07D 243/08 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2730770

The invention is concerned with novel heterocyclyl compounds of formula (I) wherein A, X, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and can be used as medicaments.

L'invention porte sur de nouveaux composés hétérocyclylés de formule (I), dans laquelle A, X, R3, R4, R5, R6, R7, R8, R9, R10, m, n et p sont tels que définis dans la description et dans les revendications, ainsi que sur des sels physiologiquement acceptables de ces composés. Ces composés sont des antagonistes du récepteur CCR2, du récepteur CCR5 et/ou du récepteur CCR3 et peuvent être utilisés en tant que médicaments.

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