A new process for the manufacturing of the compound...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 213/57 (2006.01) A61K 31/5377 (2006.01) A61P 25/18 (2006.01) C07D 213/55 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2684347

The present invention relates to a new process for the manufacture of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, and to new intermediates prepared in said process suitable for large scale manufacturing of said compound.

L'invention concerne un nouveau procédé de fabrication de 2-hydroxy-3-[5-(morpholin-4-ylméthyl)pyridin-2-yl]1H-indole-5-carbonitrile sous forme de base libre, et de sels pharmaceutiquement acceptables de ce composé, en particulier 2-hydroxy-3-[5-(morpholin-4-ylméthyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate. L'invention concerne également de nouveaux intermédiaires obtenus par ledit procédé, convenant à une fabrication à grande échelle.

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