Gene therapy method

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/79 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2334171

The invention relates to the use of an Egr-1 transcription factor polypeptide or a biologically active fragment thereof, and to nucleic acid molecules encoding such polypeptides, in the manufacture of a medicament for the treatment of wounds in a mammal, including human. In addition, it relates to a sequence that is believed to include important regions involved in the transcription of the transcription factor Egr-1 in humans and in the regulation thereof. This sequence can be used to design appropriate nucleic acid molecules and vectors that can be used in the treatment of wounds, as well as in other treatment.

L'invention concerne l'utilisation d'un polypeptide d'un facteur de transcription Egr-1, ou d'un fragment biologiquement actif de celui-ci, ainsi que l'utilisation de molécules d'acide nucléique codant pour ces polypeptides, au cours de la fabrication d'un médicament destiné à traiter les blessures d'un mammifère, notamment un humain. Cette invention concerne également une séquence qui renfermerait des régions importantes intervenant dans la transcription dudit facteur de transcription Egr-1 chez les humains, ces régions intervenant également dans la régulation de ce facteur. Cette séquence peut être utilisée pour concevoir des molécules d'acide nucléique et des vecteurs appropriés, pouvant être utilisés pour traiter des blessures ou dans tout autre traitement.

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