Process for the preparation of optically active 3-quinuclidinol

Details Process for the preparation of optically active 3-quinuclidinol Process for the preparation of optically active 3-quinuclidinol

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) C07D 453/00 (2006.01)

Patent

CA 2194727

Optically active 3-quinuclidinol is obtained by the asymmetric hydrogenation of 3-quinuclidinone, its Lewis acid adducts or its tertiary or quaternary salts, for example 1-(diphenylmethyl)-3-oxoquinuclidinium bromide. Rhodium/chiral diphosphine complexes with a metallocene structure are preferably used as catalysts. Optically active 3-quinuclidinol is a synthetic building block for pharmaceutical active substances (M1 receptor agonists).

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