Pharmaceutical compositions of levo-enantiomers of...

Details Pharmaceutical compositions of levo-enantiomers of... Pharmaceutical compositions of levo-enantiomers of...

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2232336

The levo-isomers of certain imidazole derivatives, particularly medetomidine, have been found to be inverse agonists of adrenergic .alpha.-2 receptors and are therefore useful in the prevention or treatment of conditions associated with overexpression or hypersensitization of adrenergic .alpha.-2 receptors such as obesity, a withdrawal symptom to an adrenergic .alpha.-2 receptor agonist, a neurological disorder, multiple system atrophy, diabetes mellitus, benign prostatic hyperplasia and drug-induced sensitization of adrenergic .alpha.-2 receptors. The pharmaceutical composition is preferably transdermal.

Les lévo-isomères de certains dérivés d'imidazole, notamment la médétomidine, se sont avérés être des agonistes inverses des récepteurs .alpha.-2 adrénergiques et sont par conséquent utiles dans la prévention ou le traitement d'états associés à la surexpression ou l'hypersensibilisation des récepteurs .alpha.-2 adrénergiques tels que l'obésité, le symptôme de privation de l'agoniste du récepteur .alpha.-2 adrénergique, les troubles neurologiques, l'atrophie systémique multiple, le diabète sucré, l'adénome prostatique et la sensibilisation induite par des médicaments des récepteurs .alpha.-2 adrénergiques. La composition pharmaceutique est de préférence transdermique.

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