A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 9/51 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01) A61K 47/18 (2006.01) A61K 47/32 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2489259
The present invention relates to polymeric antitumor agents in which polymeric complex micelle structures are formed by intermolecular binding or mutual interaction between styrene maleic acid copolymer (SMA) and a low molecular antitumor agent which is an anthracyclin drug such as pirarubicin, doxorubicin, epirbicin, daunorbicin, aclarubicin, or alkaloid antitumor agent such as cis-platinum or taxol. These polymeric micelle antitumor agents may improve selective accumulation of drugs to cancer tissue for improved antitumor effect, while concentrating less at normal organs or tissues, so that a lesser adverse effect may be accomplished. These polymeric antitumor agents may be prepared by dissolving SMA and a low molecular antitumor agent in aqueous solution, then in the presence of aqueous soluble carbodiimide, amino acids, or polyamine, adjusting pH to form micelle complexes, and separating and recovering the polymeric micelle component.
L'invention concerne un agent antitumeur de type polymre contenant une structure ~ complexe de polymre et de micelle form~e en r~sultat ~ une liaison ou une interaction intermol~culaire entre un agent antitumeur ~ faible teneur mol~culaire et un agent antitumeur anthracycline (par exemple, pirarubicine, doxorubicine, ~pirubicine, daunorubicine ou aclarubicine), cisplatine ou un agent antitumeur alcalo~de (par exemple taxol), et un copolymre styrne/acide mal~ique (SMA). Cet agent antitumeur de type polymre exerce d'excellents effets notamment en am~liorant l'accumulation s~lective de m~dicament sur une r~gion tumorale de manire ~ augmenter l'efficacit~ antitumeur tout en ~vitant l'accumulation sur des organes et des tissus normaux de manire ~ en r~duire les effets secondaires. Cet agent antitumeur de type polymre peut Útre obtenu par un proc~d~ consistant ~ dissoudre le SMA ainsi qu'un agent antitumeur dans un solvant ~ base aqueuse, ~ effectuer un ajustement du pH en la pr~sence de carbodiimide soluble, d'un acide amin~ ou d'une polyamine de manire ~ former une structure ~ complexe de micelle et ~ s~parer puis ~ r~cup~rer la composante polymre.
Greish Khaled
Maeda Hiroshi
Maeda Hiroshi
Smart & Biggar
LandOfFree
Polymeric micelle complexes of low molecular weight... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polymeric micelle complexes of low molecular weight..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymeric micelle complexes of low molecular weight... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1707447