Stabilized preparations for use in metered dose inhalers

Details Stabilized preparations for use in metered dose inhalers Stabilized preparations for use in metered dose inhalers

A - Human Necessities

61

K

A61K 9/72 (2006.01) A61K 9/10 (2006.01) A61K 9/12 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2304975

Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.

La présente invention concerne des dispersions stabilisées permettant de diffuser un agent bioactif dans les voies respiratoires d'un patient. De préférence, ces dispersions comprennent une pluralité de microstructures perforées dispersées dans un milieu stabilisateur qui renferme généralement un agent propulseur hydrofluoroalcane. Puisque les variations de densité entre les particules suspendues et le milieu stabilisateur sont réduites, et les forces d'attraction entre les microstructures atténuées, ces dispersions sont particulièrement résistantes à la dégradation, notamment par sédimentation ou par floculation. Dans des modes préférés de réalisation, les dispersions stabilisées peuvent être administrées aux poumons d'un patient en utilisant un aérosol-doseur.

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