Differentiation-suppressive polypeptide

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2260365

A novel human serrate-2 polypeptide consisting of a polypeptide containing the amino acid sequence described in SEQ ID NO:1 in the Sequence Listing and having the effect of regulating the differentiation of undifferentiated cells involving stem cells; its gene; a process for producing the same; and an antibody specifically recognizing the polypeptide.

L'invention a pour objet un nouveau polypeptide de serrate-2 de l'homme. Ce polypeptide contient la séquence d'acides aminés décrite dans SEQ ID NO:1 dans la liste des séquences. Ce polypeptide exerce un effet régulateur sur la différenciation cellulaire des cellules non différenciées, notamment des cellules souches. L'invention traite également du gène de ce polypeptide, et d'un procédé pour le fabriquer ainsi que d'un anticorps reconnaissant spécialement ce polypeptide.

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