New diabetes type 2 animal model

Details New diabetes type 2 animal model New diabetes type 2 animal model

A - Human Necessities

01

K

A01K 67/027 (2006.01)

Patent

CA 2534467

A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipf1/Pdx1 promoter. Also disclosed is the use of the model animal for the identification of agonists or antagonists towards GPR40, useful for the development of pharmaceuticals towards treatment of the disease.

L'invention concerne un animal de laboratoire modèle de diabètes de type 2. Cet animal renferme des cellules surexprimant GRP40 sous le contrôle du promoteur Ipf1/Pdx1. L'invention concerne également l'utilisation de ce modèle animal pour l'identification d'agonistes ou d'antagonistes de GPR40, utiles pour le développement de substances pharmaceutiques destinées à traiter les maladies susmentionnées.

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