Use of selective adenosine a1 receptor agonists, antagonists...

A - Human Necessities – 61 – K

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A61K 31/7076 (2006.01) A61K 31/00 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2414623

Angiogenesis is manipulated by administration of selective adenosine A1 allosteric enhancers can be administered in an amount effective to induce angiogenesis at a desired location for treating conditions in which increased angiogenesis is desired, such as stroke, heart disease, and peripheral vascular disease. Selective A1 antagonists can be administered in an amount effective to inhibit angiogenesis at a desired location for treating conditions in which decreased angiogenesis is desired, such as for treating tumors, diabetic retinopathy, inflammatory diseases such as rheumatoid arthritis and psoriasis.

On manipule l'angiogenèse par administration d'agonistes, d'antagonistes et/ou d'amplificateurs allostériques sélectifs du récepteur d'adénosine A1 à un patient. On peut administrer ces amplificateurs allostériques sélectifs de A1 en quantité efficace afin d'induire une angiogenèse à un emplacement désiré, de façon à traiter des états pour lesquels une augmentation de l'angiogenèse est souhaitable, tels que les attaques, les maladies cardiaques et les maladies vasculaires périphériques. On peut administrer les antagonistes sélectifs de A1 en quantités efficaces afin d'inhiber l'angiogenèse à un emplacement désiré dans le but de traiter des états nécessitant une diminution de l'angiogenèse, tels que le traitement de tumeurs, de la rétinopathie diabétique, de maladies inflammatoires, telles que la polyarthrite rhumatoïde et le psoriasis.

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