C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/00 (2006.01) C07C 69/67 (2006.01) C07D 317/30 (2006.01) C07H 5/02 (2006.01) C07H 7/02 (2006.01) C07H 15/203 (2006.01) C07H 19/073 (2006.01) C07H 19/173 (2006.01)
Patent
CA 2574651
The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro- 2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C- methyl-.beta.-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
L'invention concerne (i) un procédé permettant de préparer un dérivé 2-désoxy-2-fluoro-2-méthyl-D-ribonolactone, (ii) une conversion de la lactone en nucléosides dotés d'une puissante activité anti-VHC, et leurs analogues, et (iii) un procédé permettant de préparer les nucléosides anti-VHC contenant les nucléosides 2-désoxy-2-fluoro-2-C-méthyl-ß-D-ribofuranosyl à partir d'un nucléoside préformé, survenant, de préférence, naturellement.
Chun Byoung-Kwon
Du Jinfa
Shi Junxing
Stec Wojciech
Wang Peiyuan
Pharmasset Inc.
Ridout & Maybee Llp
LandOfFree
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