Oral formulations of medicaments

Details Oral formulations of medicaments Oral formulations of medicaments

A - Human Necessities

61

K

A61K 9/68 (2006.01) A23G 3/00 (2006.01) A23G 4/00 (2006.01) A23K 1/16 (2006.01) A23K 1/18 (2006.01) A61K 9/00 (2006.01) A61K 31/4465 (2006.01) A61K 31/5375 (2006.01) A61K 47/36 (2006.01) A61P 1/02 (2006.01)

Patent

CA 2341926

A formulation suitable for oral treatment with a medicament comprising: a solid masticable portion and one or more reservoir portions encompassed by said masticable portion; the solid masticable portion consisting of a fully edible material, having mechanical properties conducive to promoting mastication, typified by a stiffness measurement (i.e. Young's modulus) in the range of 0.01-5MPa, and compressive strength in the range of 10 to 10,000 mJ; the reservoir portion or portions comprising a releasable unit dose of the medicament in a fluid (preferably a liquid) form, with a viscosity below 800mPa.s at body temperature (ca. 36- ca.40°C), and preferably between the range of 50-200mPa.s; such that on mastication, the masticable portion is ruptured and the unit dose of the medicament is released in a short space of time from the reservoir portion into the oral cavity.

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