Combination of a chemotherapeutic agent and an antagonist of...

Details Combination of a chemotherapeutic agent and an antagonist of... Combination of a chemotherapeutic agent and an antagonist of...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/4745 (2006.01) A61K 31/513 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2570887

The invention concerns an improved method for treating tumor, including cancer, which combines the administration of a chemotherapeutic agent and an antagonist of a gene product the expression of which is upregulated by the chemotherapeutic agent. The invention further concerns methods and means for the diagnosis and classification of tumors, and for the prognosis of the outcome of tumor treatment, and patient response to a particular treatment modality.

L'invention concerne un procédé amélioré de traitement de tumeurs, y compris de tumeurs cancéreuses, qui combine l'administration d'un agent chimiothérapeutique et d'un antagoniste de produit génique dont l'expression est régulée à la hausse par l'agent chimiothérapeutique. Par ailleurs, l'invention concerne des procédés et des moyens servant à diagnostiquer et à classifier les tumeurs, ainsi qu'à pronostiquer le résultat du traitement tumoral, de même que la réponse du patient à des modalités thérapeutiques particulières.

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