A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/593 (2006.01) A61K 31/40 (2006.01) A61K 45/06 (2006.01) A61P 3/04 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2539361
The present invention relates to pharmaceutical compositions and methods of treatment comprising administering to a patient in need thereof a combination of a 2-alkylidene-19-nor-vitamin D derivative and an estrogen agonist/antagonist or a pharmaceutically acceptable salt or prodrug thereof. Particularly, the present invention relates to pharmaceutical compositions and methods of treatment comprising administering to a patient in need thereof 2- methylene-19-nor-20(S)~Ia,25-dihydroxyvitamin D3 and (-)-cis-6-phenyl-5-[4-(2- pyrrolidin-1yl-ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthalene.-2-ol, or a pharmaceutically acceptable salt or prodrug thereof.
L'invention concerne des compositions pharmaceutiques et des méthodes de traitement consistant à administrer à un patient nécessitant un tel traitement une association d'un dérivé de la 2-alkylidène-19-nor-vitamine D et d'un agoniste/antagoniste des oestrogènes ou bien de son sel ou promédicament pharmaceutiquement acceptable. Plus particulièrement, la présente invention concerne des compositions pharmaceutiques et des méthodes de traitement consistant à administrer à un patient nécessitant un tel traitement de la 2-méthylène-19-nor-20(S)-1.alpha.,25-dihydroxyvitamine D¿3? et du (-)-cis-6-phényl-5-[4-(2-pyrrolidin-1yl-éthoxy)-phényl]-5,6,7,8-tétrahydronaphtalène?.¿-2-ol, ou bien son sel ou promédicament pharmaceutiquement acceptable.
Pfizer Products Inc.
Smart & Biggar
Wisconsin Alumni Research Foundation
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