Treatment for atherosclerosis and other cardiovascular and...

Details Treatment for atherosclerosis and other cardiovascular and... Treatment for atherosclerosis and other cardiovascular and...

C - Chemistry, Metallurgy

07

C

C07C 333/14 (2006.01) A61K 31/145 (2006.01) A61K 31/185 (2006.01) A61K 31/198 (2006.01) A61K 31/27 (2006.01) A61K 31/325 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/715 (2006.01) A61K 38/05 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) C07C 333/04 (2006.01) C07C 333/08 (2006.01) C07C 333/16 (2006.01) C07D 207/06 (2006.01) C07D 279/30 (2006.01) C07D 295/21 (2006.01) C07J 41/00 (2006.01) C07K 2/00 (2006.01) C07K 5/06 (2006.01) C08B 37/00 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.0

Patent

CA 2189336

Dithiocarboxylates, including dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM- 1, and are therefore useful in the treatment of cardiovascular disease, including atherosclerosis, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.

Les dithiocarboxylates, y compris les dithiocarbamates, bloquent l'expression induite de la molécule d'adhésion de surface de cellules endothéliales VCAM-1, et conviennent ainsi au traitement des maladies cardio-vasculaires, y compris l'athérosclérose, ainsi que des maladies inflammatoires non cardio-vasculaires induites par VCAM-1.

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