C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2576113
The present invention relates to a method and kit, including parts thereof, for the prognosis of breast cancer. In particular, the method involves identifying a gene expression pattern, or molecular signature, that indicates the likelihood of survival of a patient with breast cancer, and/or likelihood of recurrence of the disease in a patient being treated, or having been treated, for breast cancer, and the likelihood of a patient having a metastatic form of cancer. Six molecular signatures, comprising twelve groups/sets of molecular markers have been identified, which have relevance in determining the prognosis of a given breast cancer. Each molecular signature comprises a plurality of genetic markers whose expression, either high or low in respect of normal tissue, is indicative of a given outcome, such as survival or recurrence.
En particulier, le procédé inclut l~identification d~un modèle d~expression génétique, incluant des parties de celui-ci, pour le pronostic du cancer du sein. En particulier, le procédé inclut l~identification d~un modèle d~expression génétique, ou signature moléculaire, qui indique la probabilité de survie d~un patient avec cancer du sein, et/ou la probabilité de récurrence de la maladie chez un patient en cours de traitement, ou ayant été traité, pour le cancer du sein, et la probabilité d~un patient d~avoir un cancer de forme métastatique. Six signatures moléculaires, comprenant douze groupes/jeux de marqueurs moléculaires ont été identifiés, qui sont pertinents pour déterminer le pronostic d~un cancer du sein. Chaque signature moléculaire comprend une pluralité de marqueurs génétiques dont l~expression, soit haute ou basse au regard d~un tissu normal, est indicatrice d~une évolution donnée, tel que résiduelle ou récurrente.
Cardiff Biologicals Limited
Smart & Biggar
University College Cardiff Consultants Limited
LandOfFree
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