C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) A61K 31/28 (2006.01) H01L 51/30 (2006.01)
Patent
CA 2303096
A binuclear DNA-threading transition metal complex with the general formula: (L1)-M1-(D1-B-D2)-M2-(L2) wherein D1-B-D2 is a bridging ligand; D1 is a polycyclic heteroaromatic ligand in which aza nitrogens can form a bidentate or tridentate chelate with M1; D2 is any bi- or oligodentate ligand co- ordinated to the transition metal M2; B is any appropriately substituted chain of at least two atoms; M1 is a transition metal ion with octahedral co- ordination sphere; M2 is any transition metal ion; L1 comprises a set of 1-3 ancillary ligands that saturate the remaining co-ordination sphere of M1; and L2 comprises a set of 1-4 ancillary ligands that saturate the remaining co- ordination sphere of M2. An example of the complex according to the invention is shown in the figure 1. The complex according to the invention is useful for treatment of different diseases, such as cancer and infections.
La présente invention concerne un complexe à métal de transition en hélice d'ADN binucléaire représenté par la formule générale (L1)-M1-(D1-B-D2)-M2-(L2) dans laquelle D1-B-D2 est un ligand formant un pont. D1 est un ligand polycyclique hétéroaromatique dans lequel les atomes aza peuvent former avec M1 un chélate bidenté ou tridenté. D2 est l'in quelconque des ligands bidentés ou oligodentés coordonné au métal de transition M2. B est une chaîne quelconque à substitution appropriée et faisant au moins deux atomes. M1 est un ion de métal de transition comportant une sphère de coordination octaédrique. L1 comporte un ensemble de un à trois ligands additionnels venant saturer la sphère de coordination restante de M2. La figure 1 montre un exemple de complexe selon l'invention. Le complexe de la présente invention convient pour le traitement de différentes affections telles que le cancer et certaines infections.
Lincoln Per
Norden Bengt
A+ Science Invest Ab
Fetherstonhaugh & Co.
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