Immunoconjugates with an intracellularly-cleavable linkage

Details Immunoconjugates with an intracellularly-cleavable linkage Immunoconjugates with an intracellularly-cleavable linkage

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2508831

The invention relates to therapeutic conjugates with improved ability to target various cancer cells containing a targeting moiety and a therapeutic moiety. The targeting and therapeutic moieties are linked via an acid cleavable linkage that increases therapeutic efficacy of the immunoconjugate.

L'invention concerne des conjugués thérapeutiques capables de cibler diverses cellules cancéreuses, contenant un fragment de ciblage et un fragment thérapeutique. Ce fragment de ciblage et ce fragment thérapeutique sont reliés par une liaison clivable acide qui augmente le rendement thérapeutique de l'immunoconjugué.

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