Method of immobilizing and orienting molecules by use of...

Details Method of immobilizing and orienting molecules by use of... Method of immobilizing and orienting molecules by use of...

C - Chemistry, Metallurgy

12

N

C12N 9/00 (2006.01) C07H 23/00 (2006.01) C07K 7/06 (2006.01) C07K 17/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/553 (2006.01)

Patent

CA 2101476

ABSTRACT An IgG1 was engineered for specific adherence to a metal-containing surface by the incorporation C-terminal metal-chelating peptide (CP) and was bound to a nickel- coated mica surface. The metal-chelating peptide intereaction enabled the imaging of the proteinusing atomic force microscopy (AFM). The homogeneous appearance and calculated dimensions of the CP derivatized protein demonstrated the regiospecific orientation and stability imparted by this peptide. The ability to stably orient biomolecules to a surface may be used advantageously in a variety of processes designed to either visualize or manipulate molecular entities.

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