Microneedle device and method for enhancing the efficacy of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/145 (2006.01) A61K 9/00 (2006.01) A61K 9/70 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 47/10 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61L 31/00 (2006.01) A61M 37/00 (2006.01) A61P 31/16 (2006.01)

Patent

CA 2729404

The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.

La présente invention concerne un procédé damélioration de limmunogénicité grâce à lutilisation dun dispositif de micro-aiguille, apte à améliorer limmunogénicité dun vaccin contre linfluenza. Dans ledit procédé damélioration de limmunogénicité grâce à lutilisation dun dispositif de micro-aiguille, un dispositif de micro-aiguille comprenant des micro-aiguilles composées dun poly (acide lactique) recouvert dun vaccin contre linfluenza est placé sur la peau, de manière à permettre ladministration transdermique du vaccin contre linfluenza. Ledit vaccin contre linfluenza comporte un antigène comprenant une souche (H1N1) de type A, une souche (H3N2) de type A, et une souche de type B en tant quingrédients actifs. Après ladite administration transdermique, de lalcool laurique est appliqué sur une partie de la peau sur laquelle le dispositif de micro-aiguille a été placé.

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