Use of radioligands to screen inhibitors of amyloid-beta...

Details Use of radioligands to screen inhibitors of amyloid-beta... Use of radioligands to screen inhibitors of amyloid-beta...

C - Chemistry, Metallurgy

12

N

C12N 9/50 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 25/28 (2006.01) C07D 223/12 (2006.01) C07D 243/24 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01) G01N 33/60 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2346099

This invention relates to a novel method of screening for inhibitors of beta- amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of A.beta. peptides.

Cette invention se rapporte à une nouvelle méthode de sélection d'inhibiteurs de la production de bêta-amyloïdes, et par conséquent d'identification de tels inhibiteurs en tant qu'agents thérapeutiques destinés au traitement de troubles neurologiques et analogues impliquant un traitement à base de protéine précurseur de bêta-amyloïde (APP) et la production de bêta-amyloïdes. En outre, cette invention se rapporte à l'identification de macromolécules impliquées dans un traitement APP et la production de bêta-amyloïdes. Les inhibiteurs identifiés par la méthode de sélection de la présente invention s'avèrent utiles pour le traitement des troubles neurologiques, tels que la maladie d'Alzheimer, qui sont associés à des taux élevés de peptides A.beta..

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