Process for the preparation of 2-alkylthiobenzonitrile...

Details Process for the preparation of 2-alkylthiobenzonitrile... Process for the preparation of 2-alkylthiobenzonitrile...

C - Chemistry, Metallurgy

07

C

C07C 319/14 (2006.01) C07C 323/62 (2006.01)

Patent

CA 2295910

This invention relates to a process for preparing compounds of formula (I) wherein R1 represents C1-6alkyl; R2 represents C1-6haloalkyl, C1-6alkyl, C1- 6haloalkoxy, C1-6alkoxy, SOnR5 or halogen; R4 represents hydrogen, C1- 6haloalkoxy, C1-6alkoxy, SOnR5 or halogen; or a 5 or 6-membered heterocyclic ring (which may be unsaturated or partially saturated) containing 1 to 3 hetero atoms selected from oxygen, nitrogen and sulphur, optionally substituted by halogen, C1-6haloalkyl, C1-6alkyl, C1-6haloalkoxy, C1-6alkoxy, SOnR5, nitro or cyano; R5 represents C1-6alkyl; and n represents 0, 1 or 2; which comprises reacting a compound of formula (II) wherein R2 and R4 are as hereinbefore and R3 represents nitro or a halogen atom selected from fluorine, chlorine and bromine, with a compound of formula R1S-X, wherein R1 is as hereinbefore defined and X is hydrogen or an alkali metal.

Cette invention concerne un procédé de préparation de composés de formule (I). Dans la formule R¿1? représente alkyle C¿1-6?; R¿2? représente haloalkyle C¿1-6?, alkyle C¿1-6?, haloalcoxy C¿1-6? , alcoxy C¿1-6?, SO¿n?R¿5? ou halogène; R¿4? représente hydrogène, haloalcoxy C¿1-6?, alcoxy C¿1-6?, SO¿n?R¿5? ou halogène, ou un anneau hétérocyclique à 5 ou 6 éléments (qui peut être non saturé ou partiellement saturé) contenant de 1 à 3 hétéroatomes sélectionnés entre oxygène, azote et soufre, facultativement substitués par halogène, haloalkyle C¿1-6?, alkyle C¿1-6?, haloalkoxy C¿1-6?, alkoxy C¿1-6?, SO¿n?R¿5?, nitro ou cyano; R¿5? représente alkyle C¿1-6?; et n représente 0, 1 ou 2; le procédé consistant à faire réagir un composé de formule (II). Dans la formule (II) R¿2? et R¿4? sont tels que définis ci-avant et R¿3? représente nitro ou un atome halogène sélectionné entre fluor, chlore et brome, avec un composée de formule R¿1?S-X, dans lequel R¿1? est tel que défini ci-avant et X représente hydrogène ou un métal alcalin.

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