Use of microsomal triglyceride transfer protein (mtp)...

Details Use of microsomal triglyceride transfer protein (mtp)... Use of microsomal triglyceride transfer protein (mtp)...

A - Human Necessities

61

K

A61K 31/435 (2006.01) A61K 31/437 (2006.01) A61P 3/00 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2413277

The invention relates to the use of inhibitors of the microsomal triglyceride transfer protein (MTP) for reducing the number of postprandial triglyceride- rich lipoprotein particles (ppTRL) or for reducing their decomposition products i.e. the cholesterol-rich "small remnant particle" (remnants). Said particles are associated with apolipoprotein B-48 (ApoB-48) and are designated as "ppTRL" in the further course of events.

L'invention concerne l'utilisation d'inhibiteurs de protéine de transfert de triglycérides microsomale (MTP) pour abaisser le taux de particules de lipoprotéine à forte teneur en triglycérides postprandiaux (ppTRL) ou pour abaisser leurs produits de décomposition, en d'autres termes les <= petites particules résiduelles >= àforte teneur en cholestérine. Lesdites particules sont associées à de l'aloliprotéine B-48 (ApoB-48) et sont qualifiées par la suite de <= ppTRL >=.

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