A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/506 (2006.01) A61K 31/41 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 45/06 (2006.01) A61P 1/16 (2006.01) A61P 11/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2730225
The invention relates to the use of a pyrimidylaminobenzamides of formula (I) wherein the radicals have the mean-ings as defined herein,or of a pharmaceutically acceptable salt thereof for the manufacture of pharmaceutical compositions for use in the treatment of fibrosis, to the use of a pyrimidylaminobenzamides of formula (I) or pharmaceutically acceptable salt thereof in the treatment of fibrosis, to a method of treating warm-blooded animals including humans suffering from fibrosis by administering to a said animal in need of such treatment an effective dose of a pyrimidyl- aminobenzamide of formula I or a pharmaceutically acceptable salt thereof, and to combinationscomprising(a) at least one pyrimidylaminobenzamides of formula (I) as and (b) at least one compound selected form AT1-receptor antagonists and ACE inhibitors and the use of such combinations in the treatment of fi-brosis, in particular hepatic fibrosis.
La présente invention concerne lutilisation de pyrimidylaminobenzamides de formule (I) où les radicaux ont les significations comme présentement définies, ou dun sel pharmaceutiquement acceptable de ceux-ci pour la fabrication de compositions pharmaceutiques pour utilisation dans le traitement de la fibrose, lutilisation de pyrimidylaminobenzamides de formule (I) ou dun sel pharmaceutiquement acceptable de ceux-ci dans le traitement de la fibrose, un procédé de traitement danimaux à sang chaud comprenant des humains souffrant de fibrose par administration audit animal nécessitant un tel traitement dune dose efficace dun pyrimidylaminobenzamide de formule I ou un sel pharmaceutiquement acceptable de celui-ci, et des combinaisons comprenant (a) au moins un pyrimidylaminobenzamide de formule (I) et (b) au moins un composé choisi parmi des antagonistes de récepteur AT1 et des inhibiteurs dACE et lutilisation de telles combinaisons dans le traitement de la fibrose, en particulier la fibrose hépatique.
Buchdunger Elisabeth
Manley Paul W.
Fetherstonhaugh & Co.
Novartis Ag
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