Ophthalmic compositions and methods of using the same

Details Ophthalmic compositions and methods of using the same Ophthalmic compositions and methods of using the same

A - Human Necessities

61

K

A61K 31/4535 (2006.01) A61P 27/14 (2006.01)

Patent

CA 2585266

Ophthalmic compositions are provided that comprise or consist essentially of (a) ketotifen or a ketotifen salt, (b) a non-ionic tonicity agent, and (c) water. The concentration of ketotifen or the ketotifen salt is preferably from 0.01 % to 0.05 %. The non-ionic tonicity agent is preferably glycerol and the concentration of the glycerol is preferably from 4 % to 7 %. The compositions preferably have an osmolality of from 400 to 875 milliosmoles/Kg. The compositions may also contain an anti-redness agent. Methods of treating allergic conjunctivitis using the ophthalmic compositions and methods of treating dry eye disease using the ophthalmic compositions are also provided.

L'invention concerne des compositions ophtalmiques contenant notamment ou essentiellement (a) du kétotifène ou un sel de kétotifène, (b) un agent de tonicité non ionique et (c) de l'eau. La concentration du kétotifène ou du sel de kétotifène est de préférence comprise entre 0,01 % et 0,05 %. L'agent de tonicité non ionique est de préférence le glycérol et la concentration du glycérol est de préférence comprise entre 4 % et 7 %. Ces compositions présentent de préférence une osmolalité de 400 à 875 milliosmoles/Kg et peuvent également contenir un agent anti-rougeur. L'invention concerne également des méthodes de traitement de la conjonctivite allergique à l'aide de ces compositions ophtalmiques et des méthodes de traitement de la maladie de l'oeil sec à l'aide desdites compositions ophtalmiques.

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