Methods of modulating nf-kb transcription factor

Details Methods of modulating nf-kb transcription factor Methods of modulating nf-kb transcription factor

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2223092

A method of modulating NF-kB transcription factor comprising administering to a human in need thereof an effective amount of a compound having formula (I), wherein R1 and R3 are independently hydrogen, -CH3, (a), or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

L'invention concerne un procédé de modulation du facteur de transcription NF-kB, selon lequel on administre à un sujet humain dont l'état le requiert, une dose efficace d'un composé ayant la formule (I) dans laquelle R?1¿ et R?3¿ représentent hydrogène indépendamment l'un de l'autre, -CH¿3?, (a) ou (b), où Ar représente phényle éventuellement substitué; R?2¿ est choisi dans le groupe comprenant pyrrolidine, hexaméthylèneamino et pipéridino; ou un sel pharmaceutiquement acceptable de solvates de ceux-ci.

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