Gene delivery system and methods of use

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) A61K 35/76 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 7/01 (2006.01) C12N 15/49 (2006.01) C12N 15/54 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2346931

A recombinant replication competent retrovirus for gene delivery and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or tissue-specific ligand or a sequence for transcriptional targeting, or a combination of both a cell- or tissue-specific ligand and a cell- or tissue-specific transcriptional targeting sequence.

Rétrovirus recombiné compétent pour la réplication utilisé pour transporter des gènes et en thérapie génique. Le rétrovirus recombiné contient une séquence d'acide nucléique hétérologue, une séquence codant un ligand à spécificité cellulaire ou tissulaire ou une séquence de ciblage transcriptionnel, ou bien encore une combinaison d'un ligand à spécificité cellulaire ou tissulaire et d'une séquence de ciblage trancriptionnel à spécificité cellulaire ou tissulaire.

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