Therapy for psychoses combining an atypical antipsychotic...

A - Human Necessities – 61 – K

Patent

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A61K 31/5513 (2006.01) A61K 31/196 (2006.01) A61K 31/551 (2006.01) A61K 45/06 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2478227

The present invention provides for a pharmaceutical composition and methods for treating psychosis comprising the combination or a first component which is an atypical antipsychotic with a second component which is a mGlu2/3 receptor agonist. The present invention also provides for a pharmaceutical composition and method of treating a psychiatric disorder comprising the combination of a first component which is an atypical antipsychotic with a second component which is a compound which allosterically enhances receptor activity for mGlu2 and/or mGlu3.

L'invention concerne une composition pharmaceutique, ainsi que des méthodes de traitement des psychoses consistant à associer un premier composant, un antipsychotique atypique, à un deuxième composant, un antagoniste du récepteur mGlu2/3. L'invention concerne également une composition pharmaceutique et une méthode de traitement de troubles psychiatriques. Ladite méthode consiste à associer un premier composant, un antipsychotique atypique, à un deuxième composant, un composé renforçant de manière allostérique l'activité du récepteur mGlu2 et/ou mGlu3.

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