C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/497 (2006.01) A61P 25/28 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2655680
The present invention relates to a heterocyclic derivative according to Formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and Alzheimer's disease.
La présente invention concerne un dérivé hétérocyclique représenté par la formule (I), dans laquelle les variables sont telles que définies dans la description, ou un sel ou solvate pharmaceutiquement acceptable de celui-ci. La présente invention concerne également une composition pharmaceutique comprenant lesdits dérivés hétérocycliques et leur utilisation en thérapie, par exemple dans le traitement ou la prévention de maladies psychiatriques où une augmentation des réponses synaptiques à médiation par les récepteurs AMPA est nécessaire, comprenant la schizophrénie, la dépression et la maladie d'Alzheimer.
Gillen Kevin James
Jamieson Craig
Maclean John Kinnaird Ferguson
Moir Elizabeth Margaret
Rankovic Zoran
Fetherstonhaugh & Co.
N.v. Organon
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