C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/08 (2006.01) A61K 39/395 (2006.01) C07D 209/48 (2006.01) C07K 14/435 (2006.01) C07K 16/44 (2006.01) C07K 17/00 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/546 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2129350
2129350 9315050 PCTABS00024 There is provided a standard for use in testing for captan in immunoassays. This standard has the structure THPD-(CH2)x-(R3)y-R1 wherein THPD is c^_i^_s^_-1,2,3,6-tetrahydrophthalimido, x is an integer from 1 to 10, R1 selected from the group consisting of -COOH, -NH2, -NO2, -SH and -OH, R3 is an aryl moiety and y is 0 or 1. Compounds of this general structure are known, they mimic the immunological reaction of captan and related compounds which are not stable in water and thus cannot be satisfactorily used as standards in testing for the presence and level of presence of captan and related compounds. There is also provided a method of carrying out such testing, utilizing such standards in which the standard (I) is coupled to a protein that is large enough to elicit an immune response in warm blooded animals, to yield compound (II). THPD-(CH2)x-(R3)y-R2-[-C*-]-[LP](II), wherein C** is a coupling agent capable of coupling a member of the group R1 to a protein, R2 is the residue remaining when R1 is coupled with coupling agent C**, C* is the residue remaining from coupling agent C** after coupling a member of the group R1 to a protein and LP is a protein of sufficient size to generate an antibody response in a warm blooded animal.
Fleeker James R.
Herzog David P.
Itak Jeanne A.
Goudreau Gage Dubuc
Ohmicron Corporation
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