Cyclic amine derivatives as inhibitors of stearoyl-coenzyme...

Details Cyclic amine derivatives as inhibitors of stearoyl-coenzyme... Cyclic amine derivatives as inhibitors of stearoyl-coenzyme...

C - Chemistry, Metallurgy

07

D

C07D 417/10 (2006.01) A61K 31/4523 (2006.01) A61P 3/00 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2651700

Cyclic amine derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

L'invention concerne des dérivés d'amines cycliques ayant la formule de structure (I), lesquels sont des inhibiteurs sélectifs de la stéaroyl-coenzyme A delta-9-désaturase (SCD1) par rapport à d'autres stéaroyl-coenzyme A désaturases connues. Les composés de la présente invention sont utiles pour la prévention et le traitement d'affections liées à la synthèse et au métabolisme anormaux des lipides, telles qu'une maladie cardiovasculaire ; l'athérosclérose ; l'obésité ; le diabète ; une maladie neurologique ; un syndrome métabolique ; la résistance à l'insuline ; et la stéatose hépatique.

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