Stabilized variants of streptomyces subtilisin inhibitor

C - Chemistry – Metallurgy – 12 – N

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C12N 15/31 (2006.01) C07K 14/81 (2006.01) C11D 3/33 (2006.01) C11D 3/37 (2006.01) C11D 3/386 (2006.01)

Patent

CA 2332564

The present invention relates to variants of Streptomyces subtilisin inhibitor (SSI) and those inhibitors having homology to SSI. Such variants are useful in conjunction with enzymes, particularly proteases, in cleaning compositions and personal care compositions. The variants comprise an amino acid substitution at position 63 corresponding to SSI. Such variants provide greater proteolytic stability in cleaning compositions and personal care compositions. The present invention also relates to cleaning compositions and personal care compositions comprising the present variants, as well as genes encoding the variants.

Variants de l'inhibiteur de subtilisine de Streptomyces (SSI) et inhibiteurs ayant une homologie avec SSI. Ces variants sont utiles en conjonction avec des enzymes, en particulier des protéases, dans des compositions de nettoyage et des compositions d'hygiène personnelle. Lesdits variants comprennent une substitution d'acide aminé en position 63 correspondant à SSI. Ces variants présentent une stabilité protéolytique améliorée dans des compositions de nettoyage et des compositions d'hygiène personnelle. La présente invention concerne également des compositions de nettoyage et des compositions d'hygiène personnelle comportant lesdits variants, ainsi que des gènes codant ces variants.

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